![]() ![]() ![]() Morriss III Distinguished Professor of Neurology, has shown that another member of this drug class reduces amyloid plaques in mice. Holtzman, MD, the Barbara Burton and Reuben M. Suvorexant comes from a family of drugs that suppress a protein called orexin that stimulates the brain to awaken from sleep. Lucey wants to determine whether a sleep drug known as suvorexant – already approved by the Food and Drug Administration (FDA) for treatment of insomnia – can intervene to slow or delay the buildup of amyloid in the brain. Lucey and colleagues have shown that poor sleep is linked to higher levels of both amyloid and tau in the brain. Soon after tangles become detectable, people start to experience memory loss and confusion. Then, a second brain protein known as tau starts collecting into toxic tangles. First, the protein amyloid beta starts building up into plaques in the brain. A major goal of our research is to find out if treating the sleep problems before people have any signs of cognitive problems can slow or even stop the progress of Alzheimer’s disease.”Īlzheimer’s disease develops slowly over the course of two decades or more. “Chronic poor sleep may put you at risk of Alzheimer’s dementia. “Patients may attribute poor sleep to just getting older, but we often find that they have an underlying sleep disorder,” said principal investigator Brendan Lucey, MD, an associate professor of neurology and director of Washington University’s Sleep Medicine Center. The trial is supported with a $7.9 million grant from the Good Ventures Foundation, a philanthropic foundation whose mission is to help humanity thrive. A positive result would point to a new approach to delaying or preventing the onset of Alzheimer’s dementia. Louis are launching a phase 2 clinical trial to study whether using medication to treat sleep problems in older adults can reduce signs of early Alzheimer’s. Researchers at Washington University School of Medicine in St. Sleep disturbances can be an early sign of a neurodegenerative condition, and they may be treatable. But daytime napping and disjointed sleep at night aren’t normal parts of aging. The TV sitcom grandpa character who always seems to fall asleep at unfortunate moments is so common it’s almost a cliché. Louis are launching a phase 2 clinical trial to study whether using medication to treat sleep problems in older adults can reduce signs of early Alzheimer’s disease. We also have satellite sites, which provide home sleep apnea testing in Bellevue at the Eastside Specialty Center, Federal Way and Shoreline.News Release Does improving sleep reduce signs of early Alzheimer’s disease?Ĭlinical trial seeks seniors with sleep issues but no cognitive problems Our team also sees patients at the Otolaryngology Head and Neck Surgery Clinic at Harborview and at UW Medicine Primary Care in Shoreline, Federal Way, Issaquah, Kent/Des Moines and Woodinville, as well as at the General Pulmonary Clinic and Regional Heart Center, both at UW Medical Center. Our primary clinic is located at Harborview and includes our main sleep testing facility and sleep medicine clinic. Located in the Ninth and Jefferson Building at Harborview Medical Center, the UW Medicine Sleep Center provides multidisciplinary assessment, treatment and follow-up consultation services for patients with suspected or diagnosed sleep-related problems, covering the full spectrum of sleep disorders, including sleep apnea, narcolepsy, insomnia, restless leg syndrome/periodic limb movement disorder and circadian rhythm abnormalities. Comprehensive sleep disorder diagnosis, treatment and follow-up services at Harborview and beyond ![]()
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